318. Urolithin B is one of the four metabolites of the Ellagic Acid/Ellagitannins family. Jose Alberto Lpez-Daz 1, Emilio lvarez-Parrilla 1, Laura A. de la Rosa 1 y Arnulfo Ramos-Jimenez 1 Inflammatory Bowel Disease Ellagitannins (the main polyphenols in pomegranate juice) are hydrolyzed to ellagic acid, and then to urolithin A (UA) derivatives. Denk et al. show that Urolithin A, a natural metabolite of pomegranate extract, enhances antigen presentation in cancer and promotes mitophagy in CD8+ T cells, resulting in generation regenerative stem cell-like memory (TSCM) cells with enhanced anti-tumor properties. It is a type of phenolic compound that is produced in the human gut after absorption of ellagitannin containing foods such as pomegranate, strawberries, Pages: 1047-1054. 9 , 41004106 (2018). (1) Background: Ellagic acid (EA) acts as a product of gut microbiota transformation to prevent insulin resistance, which is limited by high-fat diet (HFD)-induced dysbiosis. . Published online: 01 Jun 2022. Studies suggest that the ellagic acid-rich fractions and metabolites of pomegranate urolithin-A provide a protective effect against colitis . Another dietary polyphenol such as ellagic acid and ellagitannins are transformed into urolithin A (an anti-inflammatory metabolite) by Gordonibacter spp. Denk et al. Ellagic Acid . This mechanism led us to test Urolithin A, a common metabolite that promotes mitophagy and extends lifespan in C. elegans, as a possible therapeutic to delay reproductive decline. Urolithin A Interestingly, Phoenix dactylifera extract (including gallic acid, coffeic acid, and ellagic acid phytochemicals) increased cardiac and kidney PD-1 expressions in a mouse model exposed to Adriamycin . The Phoenix dactylifera extract led to attenuated cardiotoxicity and nephrotoxicity secondary to decreased oxidative stress and apoptotic pressure. Article PubMed Google Scholar . Oocyte mitophagy is critical for extended reproductive longevity In-depth analysis demonstrates that mitophagy is required for the beneficial effect of urolithin A (Ryu et al., 2016). Hum Reprod. Inflammatory Bowel Disease POMEGRANATE The Phoenix dactylifera extract led to attenuated cardiotoxicity and nephrotoxicity secondary to decreased oxidative stress and apoptotic pressure. . Various parts of the tree and fruit are used to make medicine. Urolithin B is one of the four metabolites of the Ellagic Acid/Ellagitannins family. Francisco Javier Olivas-Aguirre 1, Abraham Wall-Medrano 1, Gustavo A. Gonzlez-Aguilar 2, . 2015;31(1):55-66 ISSN 0212-1611 CODEN NUHOEQ S.V.R. gut microbiota and its functionalities (1) Background: Ellagic acid (EA) acts as a product of gut microbiota transformation to prevent insulin resistance, which is limited by high-fat diet (HFD)-induced dysbiosis. Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. The ellagitannins (ellagic acids) are metabolised to urolithins that are circulated in the plasma of consumers, thereby increasing the counts of bifidobacteria and lactobacilli. Ellagic Acid Food Funct. Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria. Article Google Scholar Effect and mechanisms of kaempferol against endometriosis Ellagic Acid Expansion of T memory stem cells with superior anti-tumor Urolithin A, a metabolite compound resulting from the transformation of ellagitannins by gut bacteria, has been reported to have anti-oxidant, anti-inflammatory, and anti-apoptotic properties. Pomegranate is a tree. Journal of Agricultural and Food Chemistry | Vol 70, No 38 In our trial, elevated urolithin A was correlated with walnut and Mankai consumption, as its precursor, ellagic acid , was found in both. Pharmaceutical Biology . Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. Urolithin Urolithin B is one of the four metabolites of the Ellagic Acid/Ellagitannins family. [ 70 ]. Urolithin A Attenuates Helicobacter pylori-Induced Damage In Vivo. Mc Cormack B, Maenhoudt N, Fincke V, Stejskalova A, Greve B, Kiesel L, et al. Another dietary polyphenol such as ellagic acid and ellagitannins are transformed into urolithin A (an anti-inflammatory metabolite) by Gordonibacter spp. Expansion of T memory stem cells with superior anti-tumor Urolithin A, a metabolite compound resulting from the transformation of ellagitannins by gut bacteria, has been reported to have anti-oxidant, anti-inflammatory, and anti-apoptotic properties. Espn JC, Larrosa M, Garca-Conesa MT, et al. Polyphenols can also detoxify gut metabolites and repress the growth of pathogenic bacteria, such as Clostridium perfringens, Clostridium difficile and Bacteroides spp. Taninos hidrolizables; bioqumica, aspectos nutricionales y analticos y efectos en la salud. Urolithin The effect of high-polyphenol Mediterranean diet on visceral Crossref | PubMed | ISI | Google Scholar; 22. Yuandi Lei, Tianyi Jiang, Liqin He, Yanping Liu, Zhanbing Sun, Weihua Deng, Lian Huang & Zhaohui Zhang. Urolithin A Attenuates Helicobacter pylori-Induced Damage In Vivo. Zhou B. Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose. 2021;36:150119. Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. Urolithin Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. In addition, plasma hippuric acid, a glycine conjugate of benzoic acid, both metabolites present in Mankai, was significantly associated with VAT reduction even after controlling for WC change. dietary polyphenols on gut microbiota, their It belongs to the class of organic compounds known as benzo-coumarins or dibenzo--pyrones.Its precursors ellagic acids and ellagitannins are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. Crossref | PubMed | ISI | Google Scholar; 22. Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway. Thus, urolithin A, the end-products of both ellagitannins and ellagic acid, extends lifespan and improves fitness during C. elegans aging and improves muscle function and exercise capacity in rodents. The gut microbiome as a modulator of healthy ageing - Nature Article Google Scholar Polyphenols can also detoxify gut metabolites and repress the growth of pathogenic bacteria, such as Clostridium perfringens, Clostridium difficile and Bacteroides spp. Activation of the miR-34a-Mediated SIRT1/mTOR Signaling 9 , 41004106 (2018). Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. dietary polyphenols on gut microbiota, their Mitophagy Urolithin A This mechanism led us to test Urolithin A, a common metabolite that promotes mitophagy and extends lifespan in C. elegans, as a possible therapeutic to delay reproductive decline. - Mitophagy Francisco Javier Olivas-Aguirre 1, Abraham Wall-Medrano 1, Gustavo A. Gonzlez-Aguilar 2, . Hum Reprod. Yuandi Lei, Tianyi Jiang, Liqin He, Yanping Liu, Zhanbing Sun, Weihua Deng, Lian Huang & Zhaohui Zhang. Taninos hidrolizables; bioqumica, aspectos nutricionales y According to a tissue distribution experiment in wild-type mice, the prostate gland rapidly takes up high concentrations of UA after oral or intraperitoneal administration (0.3 mg/mouse/dose). Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. Interestingly, Phoenix dactylifera extract (including gallic acid, coffeic acid, and ellagic acid phytochemicals) increased cardiac and kidney PD-1 expressions in a mouse model exposed to Adriamycin . The aim of this study was to investigate the synergistic effects and mechanisms of supplementation with the probiotic Weizmannia coagulans (W. coagulans) on the prevention of insulin resistance by EA; Nutr Hosp. Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats. Urolithin . Urolithin Hum Reprod. Crossref | PubMed | ISI | Google Scholar; 22. The effect of high-polyphenol Mediterranean diet on visceral Pharmaceutical Biology . 2021;36:150119. Pages: 1047-1054. According to a tissue distribution experiment in wild-type mice, the prostate gland rapidly takes up high concentrations of UA after oral or intraperitoneal administration (0.3 mg/mouse/dose). Article Google Scholar Prostate Cancer, Nutrition, and Dietary Supplements Food Funct. Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. Applied Sciences | Free Full-Text | The Use of Phytochemicals to Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria. Expansion of T memory stem cells with superior anti-tumor Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. In addition, plasma hippuric acid, a glycine conjugate of benzoic acid, both metabolites present in Mankai, was significantly associated with VAT reduction even after controlling for WC change. Taninos hidrolizables; bioqumica, aspectos nutricionales y The ellagitannins (ellagic acids) are metabolised to urolithins that are circulated in the plasma of consumers, thereby increasing the counts of bifidobacteria and lactobacilli. According to a tissue distribution experiment in wild-type mice, the prostate gland rapidly takes up high concentrations of UA after oral or intraperitoneal administration (0.3 mg/mouse/dose). [ 70 ]. Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. Among the various metabolites, Urolithin-A was found to be more dynamic by hindering the synthesis of Applied Sciences | Free Full-Text | The Use of Phytochemicals to Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria. Revisin. Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. Prostate Cancer, Nutrition, and Dietary Supplements Oocyte mitophagy is critical for extended reproductive longevity - POMEGRANATE Inflammatory Bowel Disease Revisin. Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway. The gut microbiome as a modulator of healthy ageing - Nature Urolithin 2015;31(1):55-66 ISSN 0212-1611 CODEN NUHOEQ S.V.R. Food Funct. In our trial, elevated urolithin A was correlated with walnut and Mankai consumption, as its precursor, ellagic acid , was found in both. The ellagic acid metabolites urolithin A and B differentially affect growth, adhesion, motility, and invasion of endometriotic cells in vitro. Urolithin Urolithin A Attenuates Helicobacter pylori-Induced Damage In Vivo. Pages: 1047-1054. Thus, urolithin A, the end-products of both ellagitannins and ellagic acid, extends lifespan and improves fitness during C. elegans aging and improves muscle function and exercise capacity in rodents. It is a type of phenolic compound that is produced in the human gut after absorption of ellagitannin containing foods such as pomegranate, strawberries, This mechanism led us to test Urolithin A, a common metabolite that promotes mitophagy and extends lifespan in C. elegans, as a possible therapeutic to delay reproductive decline. Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. show that Urolithin A, a natural metabolite of pomegranate extract, enhances antigen presentation in cancer and promotes mitophagy in CD8+ T cells, resulting in generation regenerative stem cell-like memory (TSCM) cells with enhanced anti-tumor properties. . Various parts of the tree and fruit are used to make medicine. It belongs to the class of organic compounds known as benzo-coumarins or dibenzo--pyrones.Its precursors ellagic acids and ellagitannins are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. The ellagic acid metabolites urolithin A and B differentially affect growth, adhesion, motility, and invasion of endometriotic cells in vitro. 318. The aim of this study was to investigate the synergistic effects and mechanisms of supplementation with the probiotic Weizmannia coagulans (W. coagulans) on the prevention of insulin resistance by EA; . Taninos hidrolizables; bioqumica, aspectos nutricionales y Among the various metabolites, Urolithin-A was found to be more dynamic by hindering the synthesis of Effect and mechanisms of kaempferol against endometriosis The Phoenix dactylifera extract led to attenuated cardiotoxicity and nephrotoxicity secondary to decreased oxidative stress and apoptotic pressure. gut microbiota and its functionalities Journal of Agricultural and Food Chemistry | Vol 70, No 38 Urolithin It belongs to the class of organic compounds known as benzo-coumarins or dibenzo--pyrones.Its precursors ellagic acids and ellagitannins are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. 2015;31(1):55-66 ISSN 0212-1611 CODEN NUHOEQ S.V.R. The gut microbiome as a modulator of healthy ageing - Nature Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. Crossref | PubMed | ISI | Google Scholar; 22. Pharmaceutical Biology Published online: 01 Jun 2022. Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats. Mc Cormack B, Maenhoudt N, Fincke V, Stejskalova A, Greve B, Kiesel L, et al. Ellagitannins (the main polyphenols in pomegranate juice) are hydrolyzed to ellagic acid, and then to urolithin A (UA) derivatives. 2021;36:150119. Denk et al. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging. Zhou B. Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose. It is a type of phenolic compound that is produced in the human gut after absorption of ellagitannin containing foods such as pomegranate, strawberries, Urolithin A Pomegranate is a tree. show that Urolithin A, a natural metabolite of pomegranate extract, enhances antigen presentation in cancer and promotes mitophagy in CD8+ T cells, resulting in generation regenerative stem cell-like memory (TSCM) cells with enhanced anti-tumor properties. 318. Taninos hidrolizables; bioqumica, aspectos nutricionales y analticos y efectos en la salud. Applied Sciences | Free Full-Text | The Use of Phytochemicals to Nutr Hosp. dietary polyphenols on gut microbiota, their Jose Alberto Lpez-Daz 1, Emilio lvarez-Parrilla 1, Laura A. de la Rosa 1 y Arnulfo Ramos-Jimenez 1 Effect and mechanisms of kaempferol against endometriosis Published online: 01 Jun 2022. Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Studies suggest that the ellagic acid-rich fractions and metabolites of pomegranate urolithin-A provide a protective effect against colitis . Another dietary polyphenol such as ellagic acid and ellagitannins are transformed into urolithin A (an anti-inflammatory metabolite) by Gordonibacter spp. Francisco Javier Olivas-Aguirre 1, Abraham Wall-Medrano 1, Gustavo A. Gonzlez-Aguilar 2, . Crossref | PubMed | ISI | Google Scholar; 22. The effect of high-polyphenol Mediterranean diet on visceral Ellagitannins (the main polyphenols in pomegranate juice) are hydrolyzed to ellagic acid, and then to urolithin A (UA) derivatives. Espn JC, Larrosa M, Garca-Conesa MT, et al. Pomegranate is a tree. Mitophagy Nutr Hosp. The ellagitannins (ellagic acids) are metabolised to urolithins that are circulated in the plasma of consumers, thereby increasing the counts of bifidobacteria and lactobacilli. Oocyte mitophagy is critical for extended reproductive longevity Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. Interestingly, Phoenix dactylifera extract (including gallic acid, coffeic acid, and ellagic acid phytochemicals) increased cardiac and kidney PD-1 expressions in a mouse model exposed to Adriamycin . Yuandi Lei, Tianyi Jiang, Liqin He, Yanping Liu, Zhanbing Sun, Weihua Deng, Lian Huang & Zhaohui Zhang. Mc Cormack B, Maenhoudt N, Fincke V, Stejskalova A, Greve B, Kiesel L, et al. Urolithin - The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging. [ 70 ]. Jose Alberto Lpez-Daz 1, Emilio lvarez-Parrilla 1, Laura A. de la Rosa 1 y Arnulfo Ramos-Jimenez 1 Taninos hidrolizables; bioqumica, aspectos nutricionales y analticos y efectos en la salud. Journal of Agricultural and Food Chemistry | Vol 70, No 38 Thus, urolithin A, the end-products of both ellagitannins and ellagic acid, extends lifespan and improves fitness during C. elegans aging and improves muscle function and exercise capacity in rodents. Article PubMed Google Scholar Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. Among the various metabolites, Urolithin-A was found to be more dynamic by hindering the synthesis of (1) Background: Ellagic acid (EA) acts as a product of gut microbiota transformation to prevent insulin resistance, which is limited by high-fat diet (HFD)-induced dysbiosis. The ellagic acid metabolites urolithin A and B differentially affect growth, adhesion, motility, and invasion of endometriotic cells in vitro. POMEGRANATE 9 , 41004106 (2018). Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Various parts of the tree and fruit are used to make medicine. gut microbiota and its functionalities Prostate Cancer, Nutrition, and Dietary Supplements In-depth analysis demonstrates that mitophagy is required for the beneficial effect of urolithin A (Ryu et al., 2016). The aim of this study was to investigate the synergistic effects and mechanisms of supplementation with the probiotic Weizmannia coagulans (W. coagulans) on the prevention of insulin resistance by EA; Polyphenols can also detoxify gut metabolites and repress the growth of pathogenic bacteria, such as Clostridium perfringens, Clostridium difficile and Bacteroides spp. Article PubMed Google Scholar Urolithin A, a metabolite compound resulting from the transformation of ellagitannins by gut bacteria, has been reported to have anti-oxidant, anti-inflammatory, and anti-apoptotic properties. In-depth analysis demonstrates that mitophagy is required for the beneficial effect of urolithin A (Ryu et al., 2016). Studies suggest that the ellagic acid-rich fractions and metabolites of pomegranate urolithin-A provide a protective effect against colitis . Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway. Espn JC, Larrosa M, Garca-Conesa MT, et al. In addition, plasma hippuric acid, a glycine conjugate of benzoic acid, both metabolites present in Mankai, was significantly associated with VAT reduction even after controlling for WC change. Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. In our trial, elevated urolithin A was correlated with walnut and Mankai consumption, as its precursor, ellagic acid , was found in both. Crossref | PubMed | ISI | Google Scholar; 22. 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